Hansenula polymorpha Tup1p is important for peroxisome degradation
نویسندگان
چکیده
منابع مشابه
Hansenula polymorpha Tup1p is important for peroxisome degradation.
In the yeast Hansenula polymorpha peroxisomes are selectively degraded upon a shift of cells from methanol to glucose-containing media. We identified the H. polymorpha TUP1 gene by functional complementation of the peroxisome degradation deficient mutant pdd2-4. Tup1 proteins function in transcriptional repression of specific sets of genes involved in various cellular processes. Our combined da...
متن کاملRemoval of Pex3p is an important initial stage in selective peroxisome degradation in Hansenula polymorpha.
Selective degradation of peroxisomes (macropexophagy) in Hansenula polymorpha involves the sequestration of individual organelles to be degraded by membranes prior to the fusion of this compartment with the vacuole and subsequent degradation of the whole organelle by vacuolar hydrolases. Here we show that Pex3p, a peroxisomal membrane protein essential for peroxisome biogenesis, escapes this au...
متن کاملHansenula polymorpha Vam7p is required for macropexophagy.
We have analyzed the functions of two vacuolar t-SNAREs, Vam3p and Vam7p, in peroxisome degradation in the methylotrophic yeast Hansenula polymorpha. A Hp-vam7 mutant was strongly affected in peroxisome degradation by selective macropexophagy as well as non-selective microautophagy. Deletion of Hp-Vam3p function had only a minor effect on peroxisome degradation processes. Both proteins were loc...
متن کاملChapter 1 General introduction: Peroxisome homeostasis in Hansenula polymorpha
Peroxisomes are essential organelles in many eukaryotes. Until recently, the main focus of the investigations concerning this important organelle was to understand the biogenesis of the peroxisome (induction, proliferation and matrix protein import). However, when peroxisomes become redundant they are quickly degraded by highly selective processes known as pexophagy. The first molecular studies...
متن کاملPeroxisome reintroduction in Hansenula polymorpha requires Pex25 and Rho1
We identified two proteins, Pex25 and Rho1, which are involved in reintroduction of peroxisomes in peroxisome-deficient yeast cells. These are, together with Pex3, the first proteins identified as essential for this process. Of the three members of the Hansenula polymorpha Pex11 protein family-Pex11, Pex25, and Pex11C-only Pex25 was required for reintroduction of peroxisomes into a peroxisome-d...
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ژورنال
عنوان ژورنال: FEMS Yeast Research
سال: 2004
ISSN: 1567-1356
DOI: 10.1016/s1567-1356(04)00054-6